Correlation Engine 2.0
Clear Search sequence regions

  • apoptosis (1)
  • Ca2 (3)
  • calcium (2)
  • female (1)
  • fetal growth (2)
  • HIF 1α (1)
  • human (5)
  • impairment (2)
  • muscle (1)
  • myometrium (5)
  • ns11021 (1)
  • pathogenesis (1)
  • pregnancies (3)
  • smooth muscle (4)
  • women (1)
  • Sizes of these terms reflect their relevance to your search.

    Objective: To investigate the relaxation responses mediated by L-type Ca2+ channels and big-conductance Ca2+-activated K+ (BKCa) channels and histological changes in the human umbilical artery (HUA) and myometrium smooth muscle isolated from pregnancies complicated with intrauterine growth restriction (IUGR).Methods: The muscle reactivity and the histology of the smooth muscle of the HUA and myometrium retrieved from 14 women with IUGR and 14 controls were investigated by the isolated tissue bath and immunohistochemical method.Results: In HUA, the maximum relaxation responses and pD2 values of nifedipine and NS11021 (BKCa channel opener) were significantly increased and significant histopathological changes are observed in the IUGR group.Conclusions: The pathogenesis of IUGR might be associated with the impairment in the functional responses of L-type Ca2+ channels and BKCa channels in HUA smooth muscle. The increased staining of myometrium and UC with HIF-1α in IUGR may indicate apoptosis, histological damage, and impaired fetal growth.


    Mustafa Sengul, Baris Karadas, Selin Acar-Sahan, Fatma Simsek, Ersan Horoz, Işık Cem Özok, Tijen Temiz. Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies. Fetal and pediatric pathology. 2023 Dec;42(6):845-859

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37578058

    View Full Text