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Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes. © 2023. Springer Nature Limited.
Citation
Anders P Mutvei, Michal J Nagiec, John Blenis. Balancing lysosome abundance in health and disease. Nature cell biology. 2023 Sep;25(9):1254-1264
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PMID: 37580388
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