Sleep-associated insulin resistance promotes neurodegeneration.

Kanagavalli Ramasubbu, Gnanasambandan Ramanathan, Ganesh Venkatraman, V Devi Rajeswari

Molecular biology reports 2023 Oct

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Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect inflammation, immunity, neurodegeneration, cognitive depletion, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly impacts brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance affects these functions by interfering with the insulin signalling pathway, neurotransmission, inflammatory pathways, and plasticity of neurons. So, in this review, We discuss the evidence that suggests that neurodegeneration occurs via sleep and is associated with insulin resistance, along with the insulin signalling pathways involved in neurodegeneration and neuroplasticity, while exploring the role of hormones in these conditions. © 2023. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

Kanagavalli Ramasubbu, Gnanasambandan Ramanathan, Ganesh Venkatraman, V Devi Rajeswari. Sleep-associated insulin resistance promotes neurodegeneration. Molecular biology reports. 2023 Oct;50(10):8665-8681