Marcella Perri, Debora Pellegrini, Claudia Uribe Roca, Fabio Gonzalez, Agustín Buero, Domingo Chimondeguy, Julio E Bruetman
Medicina 2023Stiff-person syndrome is a rare neurological condition characterized by muscular rigidity of the trunk and extremities and muscle spasms triggered by sensory or emotional stimuli, which progresses towards prostration. It has a pathophysiogenic mechanism with an immunological basis, in which autoantibodies, such as antiGAD65, play a central role. Likewise, the detection of these antibodies corroborates the diagnosis in a patient with a suggestive clinical picture. Four to 6% of cases have underlying neoplasms. Treatment is based on symptomatic, immunomodulatory, and underlying disease management in paraneoplastic cases. We report a case of classic stiff person syndrome associated with thymoma and review the main characteristics of this entity.
Marcella Perri, Debora Pellegrini, Claudia Uribe Roca, Fabio Gonzalez, Agustín Buero, Domingo Chimondeguy, Julio E Bruetman. Stiff person syndrome associated with thymoma]. Medicina. 2023;83(4):626-630
PMID: 37582138
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