Spatial and temporal expression pattern of somatostatin receptor 2 in mouse].

Mingchuan Tang, Chuan Liu, Rongyu Li, Huisang Lin, Yanli Peng, Yiming Lang, Kecao Su, Zhongliang Xie, Mingyue Li, Xiao Yang, Guan Yang, Xinjiong Fan, Yan Teng

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2023 Jul 25

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Somatostatin (SST) is an inhibitory polypeptide hormone that plays an important role in a variety of biological processes. Somatostatin receptor 2 (SSTR2) is the most widely expressed somatostatin receptor. However, the specific cell types expressing Sstr2 in the tissues have not been investigated. In this study, we detected the expression pattern of SSTR2 protein in mouse at different development stages, including the embryonic 15.5 days and the postnatal 1, 7, 15 days as well as 3 and 6 months, by multicolour immunofluorescence analyses. We found that Sstr2 was expressed in some specific cells types of several tissues, including the neuronal cells and astrocytes in the brain, the mesenchymal cells, the hematopoietic cells, the early hematopoietic stem cells, and the B cells in the bone marrow, the macrophages, the type Ⅱ alveolar epithelial cells, and the airway ciliated cells in the lung, the epithelial cells and the neuronal cells in the intestine, the hair follicle cells, the gastric epithelial cells, the hematopoietic stem cells and the nerve fibre in the spleen, and the tubular epithelial cells in the kidney. This study identified the specific cell types expressing Sstr2 in mouse at different developmental stages, providing new insights into the physiological function of SST and SSTR2 in several cell types.

Citation

Mingchuan Tang, Chuan Liu, Rongyu Li, Huisang Lin, Yanli Peng, Yiming Lang, Kecao Su, Zhongliang Xie, Mingyue Li, Xiao Yang, Guan Yang, Xinjiong Fan, Yan Teng. Spatial and temporal expression pattern of somatostatin receptor 2 in mouse]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Jul 25;39(7):2656-2668