Toll-like receptor 4: A potential therapeutic target for multiple human diseases.

Jinrui Wei, Yan Zhang, Haopeng Li, Fuquan Wang, Shanglong Yao

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct

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The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention. Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Jinrui Wei, Yan Zhang, Haopeng Li, Fuquan Wang, Shanglong Yao. Toll-like receptor 4: A potential therapeutic target for multiple human diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct;166:115338