miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma.

Merkel cell carcinoma (MCC) is a rare, aggressive form of skin malignancy with a high recurrence commonly within two to three years of initial diagnosis. The incidence of MCC has nearly doubled in the past few decades. Options for diagnosing, assessing, and treating MCC are limited. MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that play an important role in controlling many different aspects of cell biology. Many miRNAs are aberrantly expressed in distinct types of cancer, with some serving as tumor suppressors and others as oncomiRs. Therefore, the future holds great promise for the utilization of miRNAs in enhancing diagnostic, prognostic, and therapeutic approaches for MCC. Accordingly, the goal of this article is to compile, summarize, and discuss the latest research on miRNAs in MCC, highlighting their potential clinical utility as diagnostic and prognostic biomarkers. Copyright © 2023 Elsevier GmbH. All rights reserved.

Citation

Tohada M Al-Noshokaty, Mohammed S Elballal, Gouda Kamel Helal, Ahmed I Abulsoud, Shereen Saeid Elshaer, Ahmed A El-Husseiny, Doaa Fathi, Nourhan M Abdelmaksoud, Sherif S Abdel Mageed, Heba M Midan, Mohamed Bakr Zaki, Mai A Abd-Elmawla, Nehal I Rizk, Mahmoud A Elrebehy, Moataz B Zewail, Osama A Mohammed, Ahmed S Doghish. miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma. Pathology, research and practice. 2023 Sep;249:154763

Mesh Tags

Substances

PMID: 37595447

search → result