Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos.

Xinyi Lu

Journal of molecular cell biology 2024 Jan 17

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Endogenous retroviruses (ERVs) are important components of transposable elements that constitute ∼40% of the mouse genome. ERVs exhibit dynamic expression patterns during early embryonic development and are engaged in numerous biological processes. Therefore, ERV expression must be closely monitored in cells. Most studies have focused on the regulation of ERV expression in mouse embryonic stem cells (ESCs) and during early embryonic development. This review touches on the classification, expression, and functions of ERVs in mouse ESCs and early embryos and mainly discusses ERV modulation strategies from the perspectives of transcription, epigenetic modification, nucleosome/chromatin assembly, and post-transcriptional control. © The Author(s) (2023). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS.

Citation

Xinyi Lu. Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos. Journal of molecular cell biology. 2024 Jan 17;15(8)