MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells.

Hongsheng Wang, Wenxiang Sun, Javier Traba, Juan Wu, Chen-Feng Qi, Laura Amo, Hemanta K Kole, Bethany Scott, Komudi Singh, Michael N Sack, Silvia Bolland

ImmunoHorizons 2023 Aug 01

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Activated B cells experience metabolic changes that require mitochondrial remodeling, in a process incompletely defined. In this study, we report that mitochondrial antiviral signaling protein (MAVS) is involved in BCR-initiated cellular proliferation and prolonged survival. MAVS is well known as a mitochondrial-tethered signaling adaptor with a central role in viral RNA-sensing pathways that induce type I IFN. The role of MAVS downstream of BCR stimulation was recognized in absence of IFN, indicative of a path for MAVS activation that is independent of viral infection. Mitochondria of BCR-activated MAVS-deficient mouse B cells exhibited a damaged phenotype including disrupted mitochondrial morphology, excess mitophagy, and the temporal progressive blunting of mitochondrial oxidative capacity with mitochondrial hyperpolarization and cell death. Costimulation of MAVS-deficient B cells with anti-CD40, in addition to BCR stimulation, partially corrected the mitochondrial structural defects and functionality. Our data reveal a (to our knowledge) previously unrecognized role of MAVS in controlling the metabolic fitness of B cells, most noticeable in the absence of costimulatory help. Copyright © 2023 The Authors.

Citation

Hongsheng Wang, Wenxiang Sun, Javier Traba, Juan Wu, Chen-Feng Qi, Laura Amo, Hemanta K Kole, Bethany Scott, Komudi Singh, Michael N Sack, Silvia Bolland. MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells. ImmunoHorizons. 2023 Aug 01;7(8):587-599