The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses.

Stephan Scheurer, Ann-Christine Junker, Chaoqi He, Stefan Schülke, Masako Toda

Current allergy and asthma reports 2023 Oct

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Immunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of IgE-mediated allergies and induction of immune tolerance. The present review addresses the role of IgA in the manifestation of IgE-mediated allergies, including allergen-specific immunotherapy (AIT), the regulation of IgA production, and the mechanism of IgA in immune cell activation. The majority of studies report an association of IgA with the induction of immune tolerance in IgE-mediated allergies. However, reports on the involvement of humoral and mucosal IgA, IgA subtypes, monomeric and polymeric IgA, and the mechanism of IgA-mediated immune cell activation are confounding. Effects by IgA are likely mediated by alteration of microbiota, IgE-blocking capacity, or activation of inhibitory signaling pathways. However, the precise mechanism of IgA-regulation, the contribution of serum and/or mucosal IgA, and IgA1/2 subtypes, on the manifestation of IgE-mediated allergies, and the underlying immune modulatory mechanism are still elusive. © 2023. The Author(s).

Citation

Stephan Scheurer, Ann-Christine Junker, Chaoqi He, Stefan Schülke, Masako Toda. The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses. Current allergy and asthma reports. 2023 Oct;23(10):589-600