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    Pattern-recognition receptor (PRR)-triggered immunity (PTI) wards off a wide range of pathogenic microbes, playing a pivotal role in angiosperms. The model liverwort Marchantia polymorpha triggers defense-related gene expression upon sensing components of bacterial and fungal extracts, suggesting the existence of PTI in this plant model. However, the molecular components of the putative PTI in M. polymorpha and the significance of PTI in bryophytes have not yet been described. We here show that M. polymorpha has four lysin motif (LysM)-domain-containing receptor homologs, two of which, LysM-receptor-like kinase (LYK) MpLYK1 and LYK-related (LYR) MpLYR, are responsible for sensing chitin and peptidoglycan fragments, triggering a series of characteristic immune responses. Comprehensive phosphoproteomic analysis of M. polymorpha in response to chitin treatment identified regulatory proteins that potentially shape LysM-mediated PTI. The identified proteins included homologs of well-described PTI components in angiosperms as well as proteins whose roles in PTI are not yet determined, including the blue-light receptor phototropin MpPHOT. We revealed that MpPHOT is required for negative feedback of defense-related gene expression during PTI. Taken together, this study outlines the basic framework of LysM-mediated PTI in M. polymorpha and highlights conserved elements and new aspects of pattern-triggered immunity in land plants. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.


    Izumi Yotsui, Hidenori Matsui, Shingo Miyauchi, Hidekazu Iwakawa, Katharina Melkonian, Titus Schlüter, Santiago Michavila, Takehiko Kanazawa, Yuko Nomura, Sara Christina Stolze, Hyung-Woo Jeon, Yijia Yan, Anne Harzen, Shigeo S Sugano, Makoto Shirakawa, Ryuichi Nishihama, Yasunori Ichihashi, Selena Gimenez Ibanez, Ken Shirasu, Takashi Ueda, Takayuki Kohchi, Hirofumi Nakagami. LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants. Current biology : CB. 2023 Sep 11;33(17):3732-3746.e8

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    PMID: 37619565

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