A Miniature Biomedical Sensor for Rapid Detection of Schistosoma japonicum Antibodies.

Shengjie Hu, Xuecheng Jiang, Liang Yang, Xue Tang, Guofeng Yang, Yuanyuan Hu, Jie Wang, Naiyan Lu

Biosensors 2023 Aug 20

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Schistosomiasis, typically characterized by chronic infection in endemic regions, has the potential to affect liver tissue and pose a serious threat to human health. Detecting and screening for this disease early on is crucial for its prevention and control. However, existing methods encounter challenges such as low sensitivity, time-consuming processes, and complex sample handling. To address these challenges, we report a soluble egg antigen (SEA)-based functionalized gridless and meander-type AlGaN/GaN high electron mobility transistors (HEMT) sensor for the highly sensitive detection of antibodies to Schistosoma japonicum. Immobilization of the self-assembled membrane on the gate surface was verified using a semiconductor parameter analyzer, scanning electron microscope (SEM), and atomic force microscopy (AFM). The developed biosensor demonstrates remarkable performance in detecting anti-SEA, exhibiting a linear concentration range of 10 ng/mL to 100 μg/mL and a sensitivity of 0.058 mA/log (ng/mL). It also exhibits similar excellent performance in serum systems. With advantages such as rapid detection, high sensitivity, miniaturization, and label-free operation, this biosensor can fulfill the requirements for blood defense.

Citation

Shengjie Hu, Xuecheng Jiang, Liang Yang, Xue Tang, Guofeng Yang, Yuanyuan Hu, Jie Wang, Naiyan Lu. A Miniature Biomedical Sensor for Rapid Detection of Schistosoma japonicum Antibodies. Biosensors. 2023 Aug 20;13(8)