Integration of Postoperative Radiation Therapy with Cyclin-Dependent Kinase (CDK) Inhibitors.

Fernanda Hayashida Yoshimoto, Cecilia Félix Penido Mendes de Sousa, Gustavo Nader Marta, Samir Abdallah Hanna

Current oncology reports 2023 Oct

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Sequential use of radiation therapy before cyclin-dependent kinase (CDK) inhibitors in women with early breast cancer seems reasonable and with a low toxicity rate. This study aimed to evaluate the possible interaction between RT and CDK inhibitors in the adjuvant setting for patients with positive hormone receptors and HER-2 negative, investigating toxicity and the treatment sequencing. CDK inhibitors have been studied in patients with localized breast cancer and can improve invasive disease-free survival outcomes. Regarding the time of RT, all trials used CDK inhibitors after the RT. Interruptions in the CDK inhibitors were performed in 27.1% in Pallas, 17.5% in Penelope-B, and 16.6% in Monarch-E trials due to adverse events. Data from the Natalee trial are still not reported. The main adverse event grade III was neutropenia, with good resolution of the symptoms over time. CDK inhibitors applied sequentially and after RT postoperative showed a low profile of acute toxicity and suitable oncological outcomes. © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Fernanda Hayashida Yoshimoto, Cecilia Félix Penido Mendes de Sousa, Gustavo Nader Marta, Samir Abdallah Hanna. Integration of Postoperative Radiation Therapy with Cyclin-Dependent Kinase (CDK) Inhibitors. Current oncology reports. 2023 Oct;25(10):1153-1159