Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms.

Yang-Yang Zhang, Mao-Zhi Li, Hui-Hui Shen, Ayitila Abudukeyoumu, Feng Xie, Jiang-Feng Ye, Feng-Yuan Xu, Jian-Song Sun, Ming-Qing Li

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct

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Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides. Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Yang-Yang Zhang, Mao-Zhi Li, Hui-Hui Shen, Ayitila Abudukeyoumu, Feng Xie, Jiang-Feng Ye, Feng-Yuan Xu, Jian-Song Sun, Ming-Qing Li. Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct;166:115340