Mitochondrial transfer between cell crosstalk - An emerging role in mitochondrial quality control.

Intercellular signaling and component conduction are essential for multicellular organisms' homeostasis, and mitochondrial transcellular transport is a key example of such cellular component exchange. In physiological situations, mitochondrial transfer is linked with biological development, energy coordination, and clearance of harmful components, remarkably playing important roles in maintaining mitochondrial quality. Mitochondria are engaged in many critical biological activities, like oxidative metabolism and biomolecular synthesis, and are exclusively prone to malfunction in pathological processes. Importantly, severe mitochondrial damage will further amplify the defects in the mitochondrial quality control system, which will mobilize more active mitochondrial transfer, replenish exogenous healthy mitochondria, and remove endogenous damaged mitochondria to facilitate disease outcomes. This review explores intercellular mitochondrial transport in cells, its role in cellular mitochondrial quality control, and the linking mechanisms in cellular crosstalk. We also describe advances in therapeutic strategies for diseases that target mitochondrial transfer. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Yi Liu, Tinglv Fu, Guorui Li, Boyang Li, Guoqing Luo, Ning Li, Qing Geng. Mitochondrial transfer between cell crosstalk - An emerging role in mitochondrial quality control. Ageing research reviews. 2023 Aug 23;91:102038

PMID: 37625463

search → result