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Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2+ particles is analyzed by solving the system of pertaining reaction-diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2+ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2+ messengers. From the best of our knowledge, this is the first time that Ca2+ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2+ as tagged probe. Copyright © 2023 Elsevier B.V. All rights reserved.


Miljko V Satarić, Tomas Nemeš, Slobodan Zdravković. Calcium messages in flagella are faster than messenger particles. Bio Systems. 2023 Oct;232:105003

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PMID: 37625514

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