Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali.
Bocar Baya, Ibrahim Sanogo, Mahamadou Kone, Dianguina Soumare, Kadidia Ouattara, Amadou Somboro, Mamadou Wague, Nadie Coulibaly, Isaac Koloma, Mariam Coulibaly, Mohamed Nantoume, Mamadou Perou, Kadidia Kone, Djeneba Coulibaly, Hawa Boukary Diarra, Bourahima Kone, Ayouba Diarra, Mamadou D Coulibaly, Moumine Sanogo, Bassirou Diarra, Mahamadou Diakite, Chad J Achenbach, Seydou Doumbia, William R Bishai, Sabra L Klein, Jane L Holl, Souleymane Diallo, Robert L Murphy, Yacouba Toloba, Djeneba Dabitao
Journal of clinical tuberculosis and other mycobacterial diseases 2023 DecContribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis. © 2023 The Author(s).
Citation
Bocar Baya, Ibrahim Sanogo, Mahamadou Kone, Dianguina Soumare, Kadidia Ouattara, Amadou Somboro, Mamadou Wague, Nadie Coulibaly, Isaac Koloma, Mariam Coulibaly, Mohamed Nantoume, Mamadou Perou, Kadidia Kone, Djeneba Coulibaly, Hawa Boukary Diarra, Bourahima Kone, Ayouba Diarra, Mamadou D Coulibaly, Moumine Sanogo, Bassirou Diarra, Mahamadou Diakite, Chad J Achenbach, Seydou Doumbia, William R Bishai, Sabra L Klein, Jane L Holl, Souleymane Diallo, Robert L Murphy, Yacouba Toloba, Djeneba Dabitao. Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali. Journal of clinical tuberculosis and other mycobacterial diseases. 2023 Dec;33:100389
PMID: 37637324
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