Intracellular Compartmentalization: A Key Determinant of MicroRNA Functions.

Rohit Nalavade, Mohini Singh

MicroRNA (Shariqah, United Arab Emirates) 2023

filter terms:

Being an integral part of the eukaryotic transcriptome, miRNAs are regarded as vital regulators of diverse developmental and physiological processes. Clearly, miRNA activity is kept in check by various regulatory mechanisms that control their biogenesis and decay pathways. With the increasing technical depth of RNA profiling technologies, novel insights have unravelled the spatial diversity exhibited by miRNAs inside a cell. Compartmentalization of miRNAs adds complexity to the regulatory circuits of miRNA expression, thereby providing superior control over the miRNA function. This review provides a bird's eye view of miRNAs expressed in different subcellular locations, thus affecting the gene regulatory pathways therein. Occurrence of miRNAs in diverse intracellular locales also reveals various unconventional roles played by miRNAs in different cellular organelles and expands the scope of miRNA functions beyond their traditionally known repressive activities. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Rohit Nalavade, Mohini Singh. Intracellular Compartmentalization: A Key Determinant of MicroRNA Functions. MicroRNA (Shariqah, United Arab Emirates). 2023;12(2):114-130