Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia.

Minoxidil is the only US FDA approved topical drug for the treatment of androgenetic alopecia (AGA). Minoxidil is effective in hair re-growth in 30%-40% of patients and 50% of males. To exert its hair growing effect, minoxidil must be sulfonated in the scalp by the minoxidil sulfotransferase enzyme (SULT1A1). Low scalp SULT1A1 correlates with lack of minoxidil response; thus, supplementing the scalp SULT1A1 with naturally occurring minoxidil sulfotransferase enzymes could potentially improve treatment outcomes in AGA patients. In this study, we set to characterize SULT1A1 activity in various plants. From the 10 common botanical extracts we have studied, seven exhibited significant activity toward minoxidil as a substrate; thus, providing a potential novel paradigm to increase minoxidil response with natural supplements. To the best of our knowledge, this is the first study to characterize naturally occurring minoxidil sulfotransferase enzymes in plants. © 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.

Citation

Nina Mehta, Sam Huang, Rachita Dhura, Carlos Wambier, Daniel do Nascimento Fonesca, Sabrina Little, Andy Goren. Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia. Journal of cosmetic dermatology. 2024 Jan;23(1):339-343

Mesh Tags

Substances

PMID: 37638619

search → result