Chemical constituents of the marine-derived fungus Acremonium sp. AN-13.

Two new compounds named 3(S)-hydroxy-1-(2,4,5-trihydroxy-3,6- dimethylphenyl)-hex-4E-en-1-one (1) and acremonilactone (2), together with nine known compounds (3-11), were isolated from the fermentation broth of Acremonium sp. associated with marine sediments collected from South China Sea. NMR and HRESIMS spectroscopic analysis elucidated the structure of two new compounds. Compound 2 had characteristic rotary gate shape skeleton with a six-membered lactone. Compounds 1 and 9 showed DPPH radical scavenging activity with inhibition rates of 96.50 and 85.95% at the concentration of 0.5 mg/ml, respectively. Moreover, compounds 4, 6 and 11 showed definite antibacterial activity against Staphylococcus aureus ATCC 6538.

Citation

Chang-Liang An, Qing-Yun Ma, Qing-Yi Xie, Li Yang, Jing-Zhe Yuan, Hao-Fu Dai, You-Xing Zhao. Chemical constituents of the marine-derived fungus Acremonium sp. AN-13. Journal of Asian natural products research. 2024 Apr;26(4):489-496

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PMID: 37642432

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