Haoxue Wang, Yanjian Wan, Qi Liu, Xinyan Xie, Kaiheng Zhu, Qi Jiang, Yanan Feng, Pei Xiao, Zhen Xiang, Quan Zhang, Yixi Fan, Xvfang Wu, Ying Zhu, Ranran Song
Environmental science and pollution research international 2023 SepEthylene oxide is commonly used in industrial synthesis and medical disinfection. It is a known human carcinogen and has neurotoxicity. However, the association between ethylene oxide exposure and neurodevelopmental disorders remains unclear. This study aimed to evaluate the association between urinary concentrations of 2-hydroxyethyl mercapturic acid (HEMA; metabolite of ethylene oxide) and dyslexia among school-aged children. A total of 355 dyslexic children and 390 controls from three cities in China were enrolled in this case-control study from November 2017 to December 2020. Urinary HEMA was detected in 100% of the urine samples, suggesting widespread exposure to ethylene oxide in the children. Notably, the children with dyslexia had higher concentrations of urinary HEMA compared to the controls (geometric mean: 2.92 vs. 2.47 ng/mL) (P = 0.004). In the multivariable-adjusted model, urinary concentrations of HEMA were significantly associated with dyslexia risk. The individuals within the highest HEMA concentration demonstrated a 1.97-fold increased odds of dyslexia compared to those within the lowest quartile (95% confidence interval: 1.20-3.23). Thus, these findings suggested the possible link between HEMA levels and the risk of dyslexia. Further studies are warranted to validate this finding and illustrate the underlying mechanism. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Haoxue Wang, Yanjian Wan, Qi Liu, Xinyan Xie, Kaiheng Zhu, Qi Jiang, Yanan Feng, Pei Xiao, Zhen Xiang, Quan Zhang, Yixi Fan, Xvfang Wu, Ying Zhu, Ranran Song. Association between urinary 2-hydroxyethyl mercapturic acid and dyslexia among school-aged children. Environmental science and pollution research international. 2023 Sep;30(45):101091-101098
PMID: 37646928
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