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Unleashing ferroptosis for cancer therapy with warfarin.

Xiaoguang Liu, Li Zhuang, Boyi Gan

Trends in endocrinology and metabolism: TEM 2023 Nov


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  • humans (1)
  • p53 (1)
  • reductases (2)
  • tumor suppressor protein p53 (2)
  • vitamin k (5)
  • VKORC1L1 (3)
  • warfarin (4)
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    Ferroptosis holds promise for cancer therapy. A recent study by Yang et al. in Cell Metabolism reveals that VKORC1L1-mediated reduction of vitamin K inhibits ferroptosis and establishes a direct p53-VKORC1L1 link in its regulation. As warfarin can inhibit VKORC1L1, the study further underscores this drug's potential as a cancer therapy. Copyright © 2023 Elsevier Ltd. All rights reserved.

    Citation

    Xiaoguang Liu, Li Zhuang, Boyi Gan. Unleashing ferroptosis for cancer therapy with warfarin. Trends in endocrinology and metabolism: TEM. 2023 Nov;34(11):683-684

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    PMID: 37648560

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    • Copyright © 2024 Illumina Inc. All rights reserved.