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Hyperuricemia (HUA) has received wide attention as an independent risk factor for various chronic diseases. HUA is usually asymptomatic, and the related damage can be reduced by effective classification and treatment according to uric acid clearance (UAC). UAC is a calculated ratio based on the uric acid level in blood and urine. This important method is not universally used due to the inconvenience of collecting 24-h urine samples in the clinic, and most sensors are limited by the need for wide ranges and for two testing samples. In this study, a pH-sensitive urate oxidase-modified electrochemical sensor with filter membrane was proposed to calculate UAC by detecting uric acid in blood and urine. The results demonstrated that the sensor had high selectivity for uric acid with a detection limit of 0.25 μM in 5 μL spot sample, the wide linear range was 2.5-7000 μM, and the impact of the sample pH was calibrated. The linear correlation of the measurement results between the UAC sensor and clinical instrument was higher than 0.980 for 87 patients. The change in UAC in spot urine may reflect alteration in body-transport mechanisms. Thus, the UAC sensor may open a new window for the management of HUA and broaden its application in point-of-care testing. Copyright © 2023 Elsevier B.V. All rights reserved.


Anran Zheng, Zhen Guo, Chao Li, Zhiqi Zhang, Chuanyu Li, Jia Yao, Xin Wang, Jinze Li, Shasha Zhao, Weiguo Wang, Wei Zhang, Lianqun Zhou. A wide-range UAC sensor for the classification of hyperuricemia in spot samples. Talanta. 2024 Jan 01;266(Pt 2):125102

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PMID: 37651905

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