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Sinking while you swim: A dual role for CCR7 in leukocyte migration.
Science immunology 2023 SepSizes of these terms reflect their relevance to your search.
The CCR7 receptor allows dendritic cells to sense the chemokine CCL19. It also depletes CCL19 from the environment by endocytosis, leading to local gradients that can steer cells accurately and robustly through tissues, even over long distances (see related Research Article by Alanko et al.).
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Hannah Donnelly, Elena Mandrou, Robert Insall. Sinking while you swim: A dual role for CCR7 in leukocyte migration. Science immunology. 2023 Sep;8(87):eadj3102
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PMID: 37656778
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