Is placental glutathione S-Transferase (GST-P) a suitable biomarker for oral carcinogenesis: A scoping review.

Placental Glutathione S-Transferase (GST-P) can be considered a useful marker of not only of preneoplastic lesion in rat hepatocarcinogenesis and hamster pancreatic carcinogen but also as a potential marker for premalignant and malignant lesions in cases of buccal pouch mucosa. In this context, the aim of this review is to elucidate the following question whether the GST-P is a suitable biomarker for oral carcinogenesis. A total of 16 studies were carefully selected. Our results demonstrate that GST-P expression is a useful and coherent marker for oral carcinogenesis. Regarding the samples, most studies evaluated hamsters, two evaluated GST-P expression in rats and three evaluated GST-P expression in human cells. All studies demonstrated positive findings allowing us to consider such studies reliable. In summary, our conclusion is that GST-P can be a suitable biomarker for oral carcinogenesis. Copyright © 2023 Elsevier GmbH. All rights reserved.

Citation

Thiago Guedes Pinto, Patricia Ramos Cury, Ana Claudia Muniz Renno, Maria Lucia Zaidan Dagli, Daniel Araki Ribeiro. Is placental glutathione S-Transferase (GST-P) a suitable biomarker for oral carcinogenesis: A scoping review. Pathology, research and practice. 2023 Sep;249:154762

Mesh Tags

Substances

PMID: 37657165

search → result