The benefits of clustering in TNF receptor superfamily signaling.

Éva S Vanamee, Denise L Faustman

Frontiers in immunology 2023

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The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes. Copyright © 2023 Vanamee and Faustman.