Correlation Engine 2.0
Clear Search sequence regions

  • ENG (6)
  • epistaxis (1)
  • exon (1)
  • female (1)
  • gene c (2)
  • humans (1)
  • mother (3)
  • proband (5)
  • research subjects (1)
  • telangiectasia (7)
  • Sizes of these terms reflect their relevance to your search.

    Objective: To explore the genetic characteristics of a family with hereditary hemorrhagic telangiectasia (HHT) caused by endoglin (ENG) gene mutations. Methods: A total of 17 individuals from a 3-generation HHT family attending the First Affiliated Hospital of Dali University were selected as the research subjects. Clinical data and familial disease status of the HHT family proband were collected. Whole exome sequencing technology was used to screen for suspected pathogenic genes in the proband, and Sanger sequencing was used for family validation. Results: The proband and her mother had recurrent epistaxis and skin mucosal telangiectasia, and enhanced CT scans of the chest of the proband and her mother, daughter, and cousin indicated the presence of varying degrees of pulmonary arteriovenous malformations. The results of the full exon sequencing results showed that the proband carried the ENG gene c.579_599del non-shift deletion mutation, and Sanger sequencing showed that the mother, daughter, and cousin carried the same mutation. Conclusion: ENG gene c.579_ 599del mutation may be the genetic basis of HHT in this family.


    J L Ma, Z Zhou, Y Li, C Zhang, F H Duan, G M Wang. Genetic analysis of a family with hereditary hemorrhagic telangiectasia caused by endoglin gene mutation]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2023 Sep 12;46(9):916-920

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37670645

    View Full Text