Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials.

P A Vélez, V Lara-Erazo, A F Caballero-Lozada, A Botero, G Lozada, A F Velásquez, L M Villegas, A Zorrilla-Vaca

Revista espanola de anestesiologia y reanimacion 2024 Apr

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Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction; however, its use is associated with fasciculation and myalgia. We performed a systematic review and meta-analysis of randomized controlled clinical trials comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included with a total of 481 patients - 241 in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR=0.69, 95% CI 0.56-0.84, P<.001), which remained statistically significant for pregabalin (RR=0.71, 95% CI 0.54-0.93, P=.013) and gabapentin (RR=0.61, 95% CI 0.45-0.82, P=.001) separately. There was no difference in fasciculations between the groups (RR=0.92, 95% CI 0.82-1.03, P=.148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24h of surgery. Copyright © 2023. Publicado por Elsevier España, S.L.U.

Citation

P A Vélez, V Lara-Erazo, A F Caballero-Lozada, A Botero, G Lozada, A F Velásquez, L M Villegas, A Zorrilla-Vaca. Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials. Revista espanola de anestesiologia y reanimacion. 2024 Apr;71(4):324-331