Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2023 Oct

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Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success. Salvage EMCT resulted in 49% 1-month survival. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Uğur Önal, Deniz Akyol, Arda Kaya, Dilşah Başkol, Buse Kenanoglu, Gamze Şanlıdağ, Ayşe Uyan Önal, Cansu Bulut Avşar, Merve Mert, Seichan Memetali, Hüseyin Aytaç Erdem, Devrim Bozkurt, Adnan Şimşir, Osman Bozbıyık, Ümit Kahraman, Erkin Özgiray, Pervin Korkmaz, Feriha Çilli, Hüsnü Pullukçu, Tansu Yamazhan, Meltem Işıkgöz Taşbakan, Bilgin Arda, Sercan Ulusoy, Oğuz Reşat Sipahi. Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2023 Oct;42(10):1269-1273