Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review.

Xiaoqing Hao, Xiaodi Zhu, Huiqun Tian, Guanxi Lai, Wei Zhang, Honghao Zhou, Song Liu

Medicine 2023 Sep 08

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Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells' cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development. Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

Citation

Xiaoqing Hao, Xiaodi Zhu, Huiqun Tian, Guanxi Lai, Wei Zhang, Honghao Zhou, Song Liu. Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review. Medicine. 2023 Sep 08;102(36):e34671