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    RNA-guided DNA endonucleases such as those from CRISPR-Cas systems were considered limited to prokaryotes. Saito et al.1 reveal that distant eukaryotic relatives of Cas nucleases, called Fanzors, also function as RNA-guided DNA endonucleases and can be harnessed for genome editing. Copyright © 2023 Elsevier Inc. All rights reserved.


    Constantinos Patinios, Chase L Beisel. For the CRISPR Fan(zor)atics: RNA-guided DNA endonucleases discovered in eukaryotes. Molecular cell. 2023 Sep 07;83(17):3046-3048

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    PMID: 37683609

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