Significance of the cGAS-STING Pathway in Health and Disease.

Jinglin Zhou, Zhan Zhuang, Jiamian Li, Zhihua Feng

International journal of molecular sciences 2023 Aug 28

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The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic DNA sensors in mammalian cells, regulates innate immunity and the STING-dependent production of pro-inflammatory cytokines, including type-I interferon. Moreover, the cGAS-STING pathway is integral to other cellular processes, such as cell death, cell senescence, and autophagy. Activation of the cGAS-STING pathway by "self" DNA is also attributed to various infectious diseases and autoimmune or inflammatory conditions. In addition, the cGAS-STING pathway activation functions as a link between innate and adaptive immunity, leading to the inhibition or facilitation of tumorigenesis; therefore, research targeting this pathway can provide novel clues for clinical applications to treat infectious, inflammatory, and autoimmune diseases and even cancer. In this review, we focus on the cGAS-STING pathway and its corresponding cellular and molecular mechanisms in health and disease.

Citation

Jinglin Zhou, Zhan Zhuang, Jiamian Li, Zhihua Feng. Significance of the cGAS-STING Pathway in Health and Disease. International journal of molecular sciences. 2023 Aug 28;24(17)