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    Amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of Alzheimer's disease (AD). Among them, peptide deposition or plaques, is regarded as the initial factor in the pathogenesis of AD and a critical pathological hallmark in AD. This review highlights recently -specific fluorescent probes for two-photon imaging of plaques in vivo. It includes the synthesis and detection mechanism of probes, as well as their application to two-photon imaging of plaques in vivo.


    Yi Chen. Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo. Molecules (Basel, Switzerland). 2023 Aug 22;28(17)

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    PMID: 37687013

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