Clear Search sequence regions


filter terms:
  • products (9)
  • Sizes of these terms reflect their relevance to your search.

    Natural products play a key role in innovative drug discovery. To explore the potential application of natural products and their analogues in pharmacology, total synthesis is a key tool that provides natural product candidates and synthetic analogues for drug development and potential clinical trials. Deconstructive synthesis, namely building new, challenging structures through bond cleavage of easily accessible moieties, has emerged as a useful design principle in synthesizing bioactive natural products. Divergent synthesis, namely synthesizing many natural products from a common intermediate, can improve the efficiency of chemical synthesis and generate libraries of molecules with unprecedented structural diversity. In this review, we will firstly introduce five recent and excellent examples of deconstructive and divergent syntheses of natural products (2021-2023). Then, we will summarize our previous work on the deconstructive and divergent synthesis of natural products to demonstrate the high efficiency and simplicity of these two strategies in the field of total synthesis.

    Citation

    Si-Hua Hou, Feng-Fan Zhou, Yi-Hang Sun, Quan-Zhe Li. Deconstructive and Divergent Synthesis of Bioactive Natural Products. Molecules (Basel, Switzerland). 2023 Aug 22;28(17)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 37687022

    View Full Text