Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block.

Jingmin Zhong, Qingjie Wang, Yilin Xie, Zhaorong Niu, Diwei Zhou

Cytopathology : official journal of the British Society for Clinical Cytology 2024 Jan

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Mesenchymal chondrosarcoma (MC) is a rare but extremely aggressive type of chondrosarcoma distinguished by the presence of both primitive mesenchymal cells and fully developed chondroid tissue. The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1::NCOA2 fusion using next-generation sequencing, serve as vital indicators for an accurate diagnosis. © 2023 John Wiley & Sons Ltd.

Citation

Jingmin Zhong, Qingjie Wang, Yilin Xie, Zhaorong Niu, Diwei Zhou. Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block. Cytopathology : official journal of the British Society for Clinical Cytology. 2024 Jan;35(1):149-152