HIV-1-related factors interact with p53 to influence cellular processes.

Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She, Yong Wu

AIDS research and therapy 2023 Sep 10

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Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also control viral pathogenesis. For example, HIV-1 regulates the life cycle of p53, which in turn contributes significantly to HIV-1 pathogenesis. In this article, we review the interaction between HIV-1-associated factors and p53, providing information on their regulatory and molecular mechanisms, hinting possible directions for further research. © 2023. BioMed Central Ltd., part of Springer Nature.

Citation

Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She, Yong Wu. HIV-1-related factors interact with p53 to influence cellular processes. AIDS research and therapy. 2023 Sep 10;20(1):66