Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.

Alexandra N Brown-Suedel, Lisa Bouchier-Hayes

The EMBO journal 2023 Oct 16

filter terms:

all
biogroup
compound
gene and proteins
show more »
show less «

Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance. © 2023 The Authors.

Citation

Alexandra N Brown-Suedel, Lisa Bouchier-Hayes. Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome. The EMBO journal. 2023 Oct 16;42(20):e115307