The enduring enigma of sporadic chorea: A single center case series.

Pedro J Garcia Ruiz, Lola Diaz Feliz, Cici E Feliz, Isabel Lorda Sanchez, Almudena Avila Fernandez, Fiona Blanco Kelly, Maria Jose Trujillo Tiebas, Javier Del Val, Inma Navas Vinagre

Tremor and other hyperkinetic movements (New York, N.Y.) 2023

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Chorea can have a wide variety of causes including neurodegenerative, pharmacological, structural, metabolic, infectious, immunologic and paraneoplastic processes. We reviewed the clinical records of patients with apparently sporadic choreic movements and no relevant family history, who presented to our neurology department (Hospital Fundación Jimenez Diaz) between 1991 and 2022. We detected 38 cases of apparent sporadic chorea (ASC); Our analysis revealed 5 cases of genetic chorea (including 3 cases with Huntington's disease) while 6 cases were autoimmune/hematological; 6 drug-related chorea, 5 metabolic-vascular, 5 due to miscellaneous conditions and 4 were of mixed etiology. No clear etiology was identified in 8 cases. The differential diagnosis of ASC is extensive and challenging. Chorea can have a wide variety of genetic and sporadic causesWe reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 yearsWe detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic choreaThe differential diagnosis of ASC is extensive and challenging. Copyright: © 2023 The Author(s).

Citation

Pedro J Garcia Ruiz, Lola Diaz Feliz, Cici E Feliz, Isabel Lorda Sanchez, Almudena Avila Fernandez, Fiona Blanco Kelly, Maria Jose Trujillo Tiebas, Javier Del Val, Inma Navas Vinagre. The enduring enigma of sporadic chorea: A single center case series. Tremor and other hyperkinetic movements (New York, N.Y.). 2023;13:33