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When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.


Jean-Baptiste Pingault, Pasco Fearon, Essi Viding, Neil Davies, Marcus R Munafò, George Davey Smith. The providential randomisation of genotypes. The Behavioral and brain sciences. 2023 Sep 11;46:e197

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PMID: 37694914

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