The prevalence of vitamin D deficiency and associated factors in first-episode psychosis.

Vitamin D deficiency is prevalent in people with established psychotic disorders, but less is known about vitamin D levels in people with first-episode psychosis (FEP). This study aimed to determine the prevalence of vitamin D deficiency in people with FEP and identify the factors associated with vitamin D status. This was a prospective cohort study nested within a randomized controlled trial, which included 37 young people with an FEP with minimal antipsychotic medication exposure. Twenty-four percent of participants were vitamin D deficient, and a further 30% were vitamin D insufficient. There was no association between vitamin D and demographic factors or clinical symptoms (positive, negative, general psychopathology and depressive symptoms) or cognition and functioning. However, vitamin D levels were associated with season of sampling. Considering the longer-term adverse effects associated with vitamin D deficiency, it is warranted to ensure this clinical population receives supplementation if indicated. © 2023 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.

Citation

Jonathan Tsiglopoulos, Nicholas Pearson, Nathan Mifsud, Emily Castagnini, Kelly Allott, Andrew Thompson, Eoin Killackey, Patrick McGorry, Brian O'Donoghue. The prevalence of vitamin D deficiency and associated factors in first-episode psychosis. Early intervention in psychiatry. 2023 Sep 12

PMID: 37700506

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