Is the mitochondrial ATP synthesis solely H+-driven, K+,H+ symport-driven or K+/H+ antiport-driven?

Some recent literature experimental data indicate that the mitochondrial ATP synthesis might be not solely H+-driven, but K+,H+ symport-driven membrane potential-dependent, considered as a further development of Mitchell's chemiosmotic theory, in contrast to the anti-Mitchell's hypothesis of K+/H+ antiport-driven mechanism. In this short communication, the attention was pointed to a possible influence of the ionic strength of the used KCl incubation medium, versus of only K+ ions, and of the Mg2+-induced mitochondrial aggregation in the sucrose medium on the reported rates of the mitochondrial respiration and ATP synthesis. These observations were based on the own author's experimental works published earlier. Copyright © 2023. Published by Elsevier B.V.

Citation

Victor V Lemeshko. Is the mitochondrial ATP synthesis solely H+-driven, K+,H+ symport-driven or K+/H+ antiport-driven? Biochimica et biophysica acta. Biomembranes. 2023 Sep 11;1866(1):184229

PMID: 37704041

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