Tohru Miyata, Akira Shogatsudani, Ayaka Igarashi, Haruna Tsutiya, Kyouka Yoshida
Experimental animals 2024 Feb 14This study compared differences in exercise capacity as well as muscle glycogen content and degradation, and mitochondrial enzyme activity between C57BL/6J and BALB/cA mice. In exercise tests, grip strength was higher in BALB/cA mice. In Rotarod and Inverted screen test, C57BL/6J mice had significantly longer exercise durations and showed differences in motor function and muscle endurance time. Glycogen in the liver and muscle of C57BL/6J mice was significantly decreased after 20 min of swimming. Muscle glycogen content in BALB/cA mice was higher than in C57BL/6J, but swimming induced no decrease in glycogen content. Glycogen phosphorylase in muscle was inactive in the absence of AMP, and its activity increased in a concentration-dependent manner with the addition of AMP in C57BL/6J mice. In BALB/cA mice, phosphorylase activity was increased by AMP, but not further increased by higher concentrations of AMP. The citrate synthase activity in muscle did not differ between C57BL/6J and BALB/cA mice. The results of this study suggested that the reactivity of muscle glycogen phosphorylase to AMP differs among strains of mice and affects glycogen availability during exercise.
Tohru Miyata, Akira Shogatsudani, Ayaka Igarashi, Haruna Tsutiya, Kyouka Yoshida. Differences in exercise capacity and muscle glycogen metabolism in C57BL/6J and BALB/cA mice. Experimental animals. 2024 Feb 14;73(1):101-108
PMID: 37704434
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