Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2023 Sep

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We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.

Citation

Clara Maubaret, François Caméléna, Manel Mrimèche, Aymeric Braille, Mathilde Liberge, Mary Mainardis, Clémence Guillaume, Franck Noel, Cécile Bébéar, Jean-Michel Molina, Florence Lot, Emilie Chazelle, Béatrice Berçot. Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2023 Sep;28(37)