Neuroendocrine carcinoma of the cervix: About a rare case and literature review.

Neuroendocrine carcinomas of the uterine cervix are rare carcinomas, accounting for only 0.9-1.5 % of cervical tumors. Given their rarity and the absence of randomized trials, the diagnostic and therapeutic management of these tumors is complicated and is essentially modeled on that of pulmonary neuroendocrine tumors. We report a new case of large-cell neuroendocrine carcinoma of the uterine cervix, and review the various aspects of this rare entity. Neuroendocrine carcinoma is a rare and aggressive malignant tumor, It differs from squamous cell carcinoma in its higher recurrence rate and delayed diagnosis. On the other hand, association with human papillomavirus (HPV) 16 and 18 is a common risk factor for both carcinomas. To improve the survival of patients with large-cell neuroendocrine carcinomas of the uterine cervix, it is imperative to conduct multicenter clinical trials aimed at defining an effective, standardized treatment. Copyright © 2023. Published by Elsevier Ltd.

Citation

Imane El Abbassi, S O Tanguara, Y Bencherifi, M Ennachit, M Benhessou, M El Kerroumi. Neuroendocrine carcinoma of the cervix: About a rare case and literature review. International journal of surgery case reports. 2023 Oct;111:108835

PMID: 37729821

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