Follistatin and follistatin-like 3 in metabolic disorders.

Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders. So far, there were performed a few studies about their role in type 2 diabetes, obesity or gestational diabetes and even less in type 1 diabetes. The outcomes are contradictory and do not allow to draw exact conclusions. In this article we summarize the available information about connections between follistatin, as well as follistatin-like 3, and metabolic disorders. We also emphasize the strong need of performing further research to explain their exact role, especially in the pathogenesis of diabetes and obesity. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Weronika Bielka, Agnieszka Przezak, Andrzej Pawlik. Follistatin and follistatin-like 3 in metabolic disorders. Prostaglandins & other lipid mediators. 2023 Dec;169:106785

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PMID: 37739334

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