Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming.

Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of the most important innate immune cells implicated in the establishment of an immunosuppressive tumor microenvironment (TME). Recent evidence pinpoints the critical role of metabolic reprogramming in dictating pro-tumorigenic functions of TAMs. Both tumor cells and macrophages undergo metabolic reprogramming to meet energy demands in the TME. Understanding the metabolic rewiring in TAMs can shed light on immune escape mechanisms and provide insights into repolarizing TAMs towards anti-tumorigenic function. Here, we discuss how metabolism impinges on the functional divergence of macrophages and its relevance to macrophage polarization in the TME. © 2023. Italian National Cancer Institute ‘Regina Elena’.

Citation

Wentao Zeng, Fei Li, Shikai Jin, Ping-Chih Ho, Pu-Ste Liu, Xin Xie. Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming. Journal of experimental & clinical cancer research : CR. 2023 Sep 23;42(1):245

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PMID: 37740232

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