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Drawing inspiration from allosteric proteins, a zigzag-shaped π-conjugation was structurally engineered into a tweezer-like ionophore having multiple disparate binding sites. When a soft metal ion binds to the central tridentate ligand motif, the rigid backbone folds, bringing two macrocyclic arms into close proximity. Stabilized by a coordinating anion, the tweezer-like conformation of the resulting metalloligand recruits a hard cation to form a sandwich-like complex with a remarkably enhanced binding affinity and selectivity.
Citation
Suk-Il Kang, Hyun Lee, Sungryul Bae, Dongwhan Lee. Hard-Soft Cooperativity of an Allosteric Tweezer. Organic letters. 2023 Oct 06;25(39):7154-7159
PMID: 37748104
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