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Selective cyclooxygenase (COX)-2 inhibitors have several advantages over nonselective COX inhibitors (nonsteroidal anti-inflammatory drugs [NSAIDs]), including the absence of adverse effects (renal and hepatic disorders) associated with the long-term use of standard NSAIDs, as well as an improved gastrointestinal profile. The pyridazine nucleus is regarded as a promising scaffold for the development of powerful COX-2 inhibitors, particularly when selectively functionalized. This article summarizes some methods for the synthesis of pyridazine derivatives. Furthermore, it covers all of the pyridazine derivatives that have appeared as selective COX-2 inhibitors, making it useful as a reference for the rational design of novel selective COX-2 inhibitors. © 2023 Wiley Periodicals LLC.

Citation

Sara Y Ewieda, Eman M Ahmed, Rasha A Hassan, Marwa S A Hassan. Pyridazine derivatives as selective COX-2 inhibitors: A review on recent updates. Drug development research. 2023 Sep 26


PMID: 37751330

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