Synechococcus elongatus Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids.

S. elongatus is an important cyanobacterial model organism for the study of its prokaryotic circadian clock, photosynthesis, and other biological processes. It is also widely used for genetic engineering to produce renewable biochemicals. Our findings reveal an SeAgo-based defense mechanism in S. elongatus against the horizontal transfer of genetic material. We demonstrate that deletion of the ago gene facilitates genetic studies and genetic engineering of S. elongatus.

Citation

Arnaud Taton, Tami S Gilderman, Dustin C Ernst, Carla A Omaga, Lucas A Cohen, Camilo Rey-Bedon, James W Golden, Susan S Golden. Synechococcus elongatus Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids. mBio. 2023 Oct 31;14(5):e0184323

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PMID: 37791787

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