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    Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups. Copyright © 2023 Kuriyama, Sasano and Iwabuchi.

    Citation

    Yuse Kuriyama, Yusuke Sasano, Yoshiharu Iwabuchi. Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines. Frontiers in chemistry. 2023;11:1251299


    PMID: 37795386

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